Inferred Spoligoforest Topology Unravels Spatially Bimodal Distribution of Mutations in the DR Region

@article{Ozcaglar2012InferredST,
  title={Inferred Spoligoforest Topology Unravels Spatially Bimodal Distribution of Mutations in the DR Region},
  author={Cagri Ozcaglar and Amina Shabbeer and Natalia E. Kurepina and Nalin Rastogi and B{\"u}lent Yener and Kristin P. Bennett},
  journal={IEEE Transactions on NanoBioscience},
  year={2012},
  volume={11},
  pages={191-202}
}
Biomarkers of Mycobacterium tuberculosis complex (MTBC) mutate over time. Among the biomarkers of MTBC, spacer oligonucleotide type (spoligotype) and mycobacterium interspersed repetitive unit (MIRU) patterns are commonly used to genotype clinical MTBC strains. In this study, we present an evolution model of spoligotype rearrangements using MIRU patterns to disambiguate the ancestors of spoligotypes. We use a large patient dataset from the United States Centers for Disease Control and… CONTINUE READING

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