Inference of alternative splicing from RNA-Seq data with probabilistic splice graphs

@inproceedings{LeGault2013InferenceOA,
  title={Inference of alternative splicing from RNA-Seq data with probabilistic splice graphs},
  author={Laura H. LeGault and Colin N. Dewey},
  booktitle={Bioinformatics},
  year={2013}
}
MOTIVATION Alternative splicing and other processes that allow for different transcripts to be derived from the same gene are significant forces in the eukaryotic cell. RNA-Seq is a promising technology for analyzing alternative transcripts, as it does not require prior knowledge of transcript structures or genome sequences. However, analysis of RNA-Seq data in the presence of genes with large numbers of alternative transcripts is currently challenging due to efficiency, identifiability and… CONTINUE READING
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