Inference of a genetic network by a combined approach of cluster analysis and graphical Gaussian modeling

@article{Toh2002InferenceOA,
  title={Inference of a genetic network by a combined approach of cluster analysis and graphical Gaussian modeling},
  author={Hiroyuki Toh and Katsuhisa Horimoto},
  journal={Bioinformatics},
  year={2002},
  volume={18 2},
  pages={287-97}
}
MOTIVATION Recent advances in DNA microarray technologies have made it possible to measure the expression levels of thousands of genes simultaneously under different conditions. The data obtained by microarray analyses are called expression profile data. One type of important information underlying the expression profile data is the 'genetic network,' that is, the regulatory network among genes. Graphical Gaussian Modeling (GGM) is a widely utilized method to infer or test relationships among a… CONTINUE READING
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