Inference of RNA Polymerase II Transcription Dynamics from Chromatin Immunoprecipitation Time Course Data

@article{Maina2013InferenceOR,
  title={Inference of RNA Polymerase II Transcription Dynamics from Chromatin Immunoprecipitation Time Course Data},
  author={Ciira wa Maina and Antti Honkela and Filomena Matarese and Korbinian Grote and Hendrik G. Stunnenberg and George Reid and Neil D. Lawrence and Magnus Rattray},
  journal={PLoS Computational Biology},
  year={2013},
  volume={10}
}
Gene transcription mediated by RNA polymerase II (pol-II) is a key step in gene expression. The dynamics of pol-II moving along the transcribed region influence the rate and timing of gene expression. In this work, we present a probabilistic model of transcription dynamics which is fitted to pol-II occupancy time course data measured using ChIP-Seq. The model can be used to estimate transcription speed and to infer the temporal pol-II activity profile at the gene promoter. Model parameters are… 

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