Inference for meta-analysis with a suspected temporal trend.

Abstract

There is sometimes a clear evidence of a strong secular trend in the treatment effect of studies included in a meta-analysis. In such cases, estimating the present-day treatment effect by meta-regression is both reasonable and straightforward. We however consider the more common situation where a secular trend is suspected, but is not strongly statistically… (More)
DOI: 10.1002/bimj.200900307

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