Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms.

@article{Hishiki2010InfectivityOH,
  title={Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms.},
  author={Takayuki Hishiki and Yuko Shimizu and Reiri Tobita and Kazuo Sugiyama and Kazuya Ogawa and Kenji Funami and Yuki Ohsaki and Toyoshi Fujimoto and Hiroshi Takaku and Takaji Wakita and Thomas F Baumert and Yusuke Miyanari and Kunitada Shimotohno},
  journal={Journal of virology},
  year={2010},
  volume={84 22},
  pages={
          12048-57
        }
}
Hepatitis C virus (HCV) is a causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV in circulating blood associates with lipoproteins such as very low density lipoprotein (VLDL) and low-density lipoprotein (LDL). Although these associations suggest that lipoproteins are important for HCV infectivity, the roles of lipoproteins in HCV production and infectivity are not fully understood. To clarify the roles of lipoprotein in the HCV life cycle, we analyzed the… CONTINUE READING
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