Infectivity of Trichinella isolates in mice is determined by host immune responsiveness.

@article{BolsFernndez1989InfectivityOT,
  title={Infectivity of Trichinella isolates in mice is determined by host immune responsiveness.},
  author={Francisco Bol{\'a}s-Fern{\'a}ndez and Derek R. Wakelin},
  journal={Parasitology},
  year={1989},
  volume={99 Pt 1},
  pages={83-8}
}
A comparison was made of the development, survival and reproduction of 5 isolates of Trichinella spiralis in inbred mice. Low responder C57BL/10 mice allowed worms of all isolates to survive longer and reproduce more successfully than did high responder NIH mice, suggesting that host immunity exerted a dominant influence upon infectivity. One isolate (Is-5 (W) -an arctic isolate) had a markedly lower infectivity than all other isolates, and was selected for more detailed study, together with… CONTINUE READING