Infectious origins of, and molecular mimicry in, Guillain-Barré and Fisher syndromes.

  title={Infectious origins of, and molecular mimicry in, Guillain-Barr{\'e} and Fisher syndromes.},
  author={Nobuhiro Yuki},
  journal={The Lancet. Infectious diseases},
  volume={1 1},
Guillain-Barré syndrome (GBS), characterised by limb weakness and areflexia, is the prototype of postinfectious autoimmune diseases, and Campylobacter jejuni is the most frequent antecedent pathogen. GBS subsequent to C jejuni enteritis is associated with a severe, pure motor axonal variant and IgG antibodies against GM1, GM1b, GD1a, or GalNAc-GDla, gangliosides expressed in human peripheral nerves. Lipopolysaccharides of C jejuni isolated from GBS patients have ganglioside-like epitopes… CONTINUE READING
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