A case of viral hepatitis with hemolytic crisis is an Algerian boy presenting a G-6-P-D deficiency is reported. Hemolysis in G-6-P-D deficient individuals may be precipitated by some viral infection particularly viral hepatitis. During the course of this disease, the destruction of erythrocytes may be explained by an accumulation of metabolites capable of oxidizing hemoglobin SH groups, in the same way as a direct viral perturbation of the red cells glycolytic ways. The two mechanisms do not permit the normal reduction of oxidized hemoglobin. Though, these two diseases are very usual in some countries, this case in uncommon and must be well known.