Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway.

@article{Chu2004InfectiousEO,
  title={Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway.},
  author={Justin Jang-hann Chu and Mah Lee Mary Ng},
  journal={Journal of virology},
  year={2004},
  volume={78 19},
  pages={10543-55}
}
The pathway of West Nile flavivirus early internalization events was mapped in detail in this study. Overexpression of dominant-negative mutants of Eps15 strongly inhibits West Nile virus (WNV) internalization, and pharmacological drugs that blocks clathrin also caused a marked reduction in virus entry but not caveola-dependent endocytosis inhibitory agent, filipin. Using immunocryoelectron microscopy, WNV particles were seen within clathrin-coated pits after 2 min postinfection. Double… CONTINUE READING
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