Infectious disease persistence when transmission varies seasonally.

  title={Infectious disease persistence when transmission varies seasonally.},
  author={Brian G. Williams and Christina Dye},
  journal={Mathematical biosciences},
  volume={145 1},
The generation reproduction number, R0, is the fundamental parameter of population biology. Communicable disease epidemiology has adopted R0 as the threshold parameter, called the basic case reproduction number (or ratio). In deterministic models, R0 must be greater than 1 for a pathogen to persist in its host population. Some standard methods of estimating R0 for an endemic disease require measures of incidence, and the theory underpinning these estimators assumes that incidence is constant… CONTINUE READING