Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance

@inproceedings{Hsu2015InfectiousDV,
  title={Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance},
  author={Alan Yi-Hui Hsu and Shang-Rung Wu and J. W. Tsai and Po-Lin Chen and Ya-ping Chen and Thomas Ying-Jeh Chen and Yu-Chih Lo and Tzu-Chuan Ho and Meed Lee and Min-Ting Chen and Yen-Chi Chiu and Guey Chuen Perng},
  booktitle={Scientific reports},
  year={2015}
}
The levels of neutralizing antibody to a pathogen are an effective indicator to predict efficacy of a vaccine in trial. And yet not all the trial vaccines are in line with the theory. Using dengue virus (DENV) to investigate the viral morphology affecting the predictive value, we evaluated the viral morphology in acute dengue plasma compared to that of Vero cells derived DENV. The virions in plasma were infectious and heterogeneous in shape with a "sunny-side up egg" appearance, viral RNA was… CONTINUE READING
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