Infectious complications in sickle cell disease are influenced by HLA class II alleles.

@article{Tamouza2002InfectiousCI,
  title={Infectious complications in sickle cell disease are influenced by HLA class II alleles.},
  author={Ryad Tamouza and Maria Grazia Neonato and Marc Busson and François Marzais and Robert Girot and Dominique Labie and Jacques Elion and Dominique Charron},
  journal={Human immunology},
  year={2002},
  volume={63 3},
  pages={
          194-9
        }
}
Despite systematic antibiotic therapy, severe infections (septicemia, meningitis, or osteomyelitis) are a major cause of mortality and morbidity in children with sickle cell disease (SCD). In this study, we explored the possibility that polymorphism at the human leukocyte antigen (HLA) locus might constitute an immunogenetic modifying factor to the intrinsic susceptibility to infection in patients with SCD. A cohort of 80 SCD patients living in Paris, 43 with at least one major infectious… CONTINUE READING
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