Infectious bursal disease virus capsid protein VP3 interacts both with VP1, the RNA-dependent RNA polymerase, and with viral double-stranded RNA.

@article{Tacken2002InfectiousBD,
  title={Infectious bursal disease virus capsid protein VP3 interacts both with VP1, the RNA-dependent RNA polymerase, and with viral double-stranded RNA.},
  author={Mirriam G. J. Tacken and Ben Peeters and Adri A. M. Thomas and Peter J. M. Rottier and Hein J. Boot},
  journal={Journal of virology},
  year={2002},
  volume={76 22},
  pages={
          11301-11
        }
}
Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus of the Birnaviridae family. Its two genome segments are encapsidated together with multiple copies of the viral RNA-dependent RNA polymerase, VP1, in a single-shell capsid that is composed of VP2 and VP3. In this study we identified the domains responsible for the interaction between VP3 and VP1. Using the yeast two-hybrid system we found that VP1 binds to VP3 through an internal domain, while VP3 interacts with VP1… CONTINUE READING

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