Infectious and immunosuppressive complications of purine analog therapy.

  title={Infectious and immunosuppressive complications of purine analog therapy.},
  author={Bruce D Cheson},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={13 9},
  • Bruce D Cheson
  • Published 1995 in
    Journal of clinical oncology : official journal…
PURPOSE The purine analogs fludarabine, cladribine, and pentostatin are active agents in the treatment of indolent lymphoid malignancies. This report reviews the pattern, severity, and consequences of the immunosuppression and myelotoxicity associated with these agents. METHODS The literature was searched using MedLine and Cancerline, as well as the bibliographies of published reports through the winter of 1994 and 1995. RESULTS Each of these drugs induces profound lymphocytopenia. A marked… CONTINUE READING


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