Infectious agents associated with schizophrenia: A meta-analysis

@article{Arias2012InfectiousAA,
  title={Infectious agents associated with schizophrenia: A meta-analysis},
  author={Isabel Arias and Antonio Sorl{\'o}zano and Enrique Villegas and Juan de Dios Luna and Kathryn McKenney and Jorge A. Cervilla and Blanca Guti{\'e}rrez and Jos{\'e} Guti{\'e}rrez},
  journal={Schizophrenia Research},
  year={2012},
  volume={136},
  pages={128-136}
}
Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and… Expand
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References

SHOWING 1-10 OF 122 REFERENCES
Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis.
TLDR
The results suggest that individuals with schizophrenia have an increased prevalence of antibodies to T. gondii, and this association is consistent with other epidemiological studies as well as with animal studies. Expand
Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10
TLDR
Chlamydophila infections represent the highest risk factor yet found to be associated with schizophrenia, and this risk is even further enhanced in carriers of the HLA-A10 genotype. Expand
Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects.
TLDR
Serious viral CNS infections during childhood appear to be associated with the later development of schizophrenia and nonaffective psychoses, and the association with specific viruses suggests that the risk is related to infectious agents with a propensity to invade the brain parenchyma. Expand
Retroviruses and schizophrenia in Jamaica
TLDR
Results show that HTLV-I and the other retroviruses tested do not play a primary etiological role in Jamaican schizophrenics, indicating that the virus is not endemic in the Caribbean Islands and not known to be neuropathogenic. Expand
Toxoplasma and schizophrenia
TLDR
The establishment of a firm association between Toxoplasma and the aetiology of schizophrenia and related disorders would represent a major breakthrough in the understanding of these disorders and would lead to novel methods for their treatment and prevention. Expand
Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology
TLDR
This article critically review genetic and other epidemiological findings and discusses the insights they provide into the causes of schizophrenia and questions basic assumptions about the etiology and nature of schizophrenia appear critical to improving understanding about its causation. Expand
Toxoplasma gondii as a Risk Factor for Early-Onset Schizophrenia: Analysis of Filter Paper Blood Samples Obtained at Birth
TLDR
An association between Toxoplasma gondii immunoglobulin G levels corresponding to the upper quartile among control subjects were significantly associated with schizophrenia risk, and further studies are needed to establish if the association is causal and if it generalizes to cases with onset after age 18. Expand
Antiretroviral antibodies: implications for schizophrenia, schizophrenia spectrum disorders, and bipolar disorder
TLDR
Exposure to retroviral antigens related to those of HIV-1 in subpopulations of schizophrenic, schizophrenic spectrum disorder, and bipolar disorder patients is suggested. Expand
High risk of schizophrenia and other mental disorders associated with chlamydial infections: hypothesis to combine drug treatment and adoptive immunotherapy.
TLDR
Treatment with in vitro-activated immune cells together with antibiotic modalities showed sustained mental improvements in patients that did not depend on treatment with antipsychotic drugs, and hypothesize that the intracellular parasites Chlamydiaceae are main pathogenic factors in schizophrenia. Expand
The schizophrenia and Toxoplasma gondii connection: Infectious, immune or both?
TLDR
This study found that IgG T gondii antibodies were significantly higher in schizophrenia patients compared with controls, and supports the theory that toxoplasmic agents may have a role in the aetiology of schizophrenia. Expand
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