Infectious SARS-CoV-2 in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection

  title={Infectious SARS-CoV-2 in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection},
  author={Oluwasanmi Adenaiye and Jianyu Lai and P. Jacob Bueno de Mesquita and Filbert Hong and Somayeh Youssefi and Jennifer German and Sheldon Tai and Barbara Albert and Maria Telma Gomes Schanz and Stuart M. Weston and Jun Hang and Christian K. Fung and Hye Kyung Chung and Kristen Kelli Coleman and Nicolae Sapoval and Todd J. Treangen and Irina Maljkovic Berry and Kristin E. Mullins and Matthew B. Frieman and Tianzhou Ma and Donald K. Milton},
  journal={Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
  • Oluwasanmi Adenaiye, Jianyu Lai, D. Milton
  • Published 13 August 2021
  • Medicine, Biology
  • Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background: SARS-CoV-2 epidemiology implicates airborne transmission; mask source-control efficacy for, variant impact on, and infectiousness of aerosols are not well understood. Methods: We recruited COVID-19 cases to give blood, saliva, mid-turbinate and fomite (phone) swabs, and 30-minute breath samples while vocalizing into a Gesundheit-II, with and without masks at up to two visits two days apart. We quantified and sequenced viral RNA, cultured virus, and assayed sera for anti-spike and… 
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