Infections with Pseudomonas aeruginosa in patients with cystic fibrosis.

  title={Infections with Pseudomonas aeruginosa in patients with cystic fibrosis.},
  author={Burkhard T{\"u}mmler and Jutta Bo\sshammer and Stefanie Breitenstein and Inka Brockhausen and Peter Gudowius and Christine Herrmann and S L Herrmann and Thomas Heuer and P Kubesch and Frauke Mekus and Ute R{\"o}mling and Klaus D. Schmidt and Christian Spangenberg and Siegbert Walter},
  journal={Behring Institute Mitteilungen},
The lung infection with Pseudomonas aeruginosa is regarded as one of the major causes of health decline in patients with cystic fibrosis (CF). The CF host response to the persistent bacterial antigen load in the endobronchiolar lumen is characterized by a pronounced humoral response, local production of cytokines, influx of neutrophils into the lung and a protease-protease inhibitor imbalance predominantly sustained by released neutrophil elastase. CF is an autosomal recessive disease, and we… CONTINUE READING


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