Infections in children and adolescents with juvenile idiopathic arthritis and inflammatory bowel disease treated with tumor necrosis factor-α inhibitors: systematic review of the literature.

@article{Toussi2013InfectionsIC,
  title={Infections in children and adolescents with juvenile idiopathic arthritis and inflammatory bowel disease treated with tumor necrosis factor-α inhibitors: systematic review of the literature.},
  author={Sima Shelly Toussi and Nancy Pan and Heather M. Walters and Thomas J Walsh},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2013},
  volume={57 9},
  pages={1318-30}
}
Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly administered to children and adolescents with juvenile idiopathic arthritis (JIA) and pediatric inflammatory bowel disease (pIBD). Adult studies indicate that TNF-α inhibitors lead to an increased risk of serious infections compared to other disease-modifying antirheumatic drugs. We report herein a systematic literature review detailing the epidemiology and types of infections reported in children with JIA and pIBD treated with TNF… CONTINUE READING
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