Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder

  title={Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder},
  author={Faith B Dickerson and John J. Boronow and Cassie R. Stallings and Andrea E. Origoni and Sara Cole and Bogdana Krivogorsky and Robert H. Yolken},
  journal={Biological Psychiatry},

Impaired functioning in euthymic patients with bipolar disorder — HSV-1 as a predictor

Persistent infection with neurotropic herpes viruses and cognitive impairment

Latent/persistent herpes virus infections can be associated with cognitive impairments regardless of other health status, including schizophrenia patients or older community dwellers.

Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia.

Two cross-sectional studies fulfill several Bradford-Hill criteria, suggesting etiological links between HSV1 exposure and cognitive impairment, and a proof-of-concept double-blind placebo-controlled trial indicated improvement in cognitive performance following supplemental anti-herpes-specific medication among HSV 1 seropositive schizophrenia patients.

Exploring the associations of herpes simplex virus infection and cognitive dysfunction in schizophrenia: Studies in India

Indian studies are consistent with a causative role for HSV-1 in cognitive dysfunction regardless of SZ diagnosis; more rigorous studies of the causal hypothesis are needed, particularly larger randomized controlled trials.

The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.

The COMT Val158Val genotype and serological evidence of infection with HSV-1 are independent risk factors for cognitive impairment in individuals with bipolar disorder, particularly in the domains of immediate and delayed memory.

Exposure to herpes simplex virus, type 1 and reduced cognitive function.




Association of serum antibodies to herpes simplex virus 1 with cognitive deficits in individuals with schizophrenia.

Serologic evidence of herpes simplex virus 1 infection is associated with cognitive impairment in schizophrenia and is an independent predictor of cognitive dysfunction in individuals with schizophrenia.

Cognitive and psychiatric impairment in herpes simplex virus encephalitis suggest involvement of the amygdalo-frontal pathways

MRI volumetric measurements in HSVE could be a good indicator of long-term prognosis for behavioural changes related to an amygdala and frontal dysfunction and detection of HSV DNA in the cerebrospinal fluid by polymerase chain reaction.

Neuropsychology of bipolar disorder: a review.

Neuropsychology of bipolar disorder

This research has demonstrated biases for processing positive and negative stimuli in patients with mania and depression, respectively, and neuroimaging studies of the neural regions that underlie cognitive processing of affective meaning suggest the medial and orbitofrontal prefrontal cortex may be particularly involved.

Neuropsychological function in euthymic patients with bipolar disorder

These findings provide good evidence for the existence of neuropsychological impairment in patients with euthymic bipolar disorder, although the possible effect of medication should not be overlooked.

Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study.

The findings support the presence of persistent neurocognitive difficulties in patients with long-standing bipolar disorder who are not in the psychiatrically acute state or who are suffering the effects of alcohol abuse and suggest that there may be an aggregate negative effect of lifetime duration of bipolar illness on memory and frontal or executive systems.

Psychosis and herpes simplex encephalitis.

This case stresses the possibility of herpes simplex encephalitis in patients with an acute mental change with a history of a schizo-affective disorder.

Herpes simplex encephalitis: long term magnetic resonance imaging and neuropsychological profile.

Severity of amnesia showed a significant relation with severity of damage to medical limbic system structures such as the hippocampus, with bilateral damage being particularly important.

Cognitive Outcome in Acute Sporadic Encephalitis

The current knowledge about non-HSV encephalitides is summarized and more active neuropsychological research in the area is called upon.

Predictors of seropositivity to herpes simplex virus type 2 in women.

The findings show that infection with HSV-2 is associated with a wider range of morbidity and also emphasize the role of male sexual partner selection in the transmission of infection.