Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder

@article{Dickerson2004InfectionWH,
  title={Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder},
  author={Faith B Dickerson and John J. Boronow and Cassie R. Stallings and Andrea E. Origoni and Sara Cole and Bogdana Krivogorsky and Robert H. Yolken},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={588-593}
}

Impaired functioning in euthymic patients with bipolar disorder — HSV-1 as a predictor

Persistent infection with neurotropic herpes viruses and cognitive impairment

Latent/persistent herpes virus infections can be associated with cognitive impairments regardless of other health status, including schizophrenia patients or older community dwellers.

Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia.

Two cross-sectional studies fulfill several Bradford-Hill criteria, suggesting etiological links between HSV1 exposure and cognitive impairment, and a proof-of-concept double-blind placebo-controlled trial indicated improvement in cognitive performance following supplemental anti-herpes-specific medication among HSV 1 seropositive schizophrenia patients.

Exploring the associations of herpes simplex virus infection and cognitive dysfunction in schizophrenia: Studies in India

Indian studies are consistent with a causative role for HSV-1 in cognitive dysfunction regardless of SZ diagnosis; more rigorous studies of the causal hypothesis are needed, particularly larger randomized controlled trials.

The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.

The COMT Val158Val genotype and serological evidence of infection with HSV-1 are independent risk factors for cognitive impairment in individuals with bipolar disorder, particularly in the domains of immediate and delayed memory.

Exposure to herpes simplex virus, type 1 and reduced cognitive function.

...

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Serologic evidence of herpes simplex virus 1 infection is associated with cognitive impairment in schizophrenia and is an independent predictor of cognitive dysfunction in individuals with schizophrenia.

Cognitive and psychiatric impairment in herpes simplex virus encephalitis suggest involvement of the amygdalo-frontal pathways

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The findings show that infection with HSV-2 is associated with a wider range of morbidity and also emphasize the role of male sexual partner selection in the transmission of infection.