Infection with foot-and-mouth disease virus results in a rapid reduction of MHC class I surface expression.

  title={Infection with foot-and-mouth disease virus results in a rapid reduction of MHC class I surface expression.},
  author={Arantza Sanz-Parra and Francisco Sobrino and Victoria Ley},
  journal={The Journal of general virology},
  volume={79 ( Pt 3)},
The modulation of MHC class I molecule expression on the surface of cells as a consequence of foot-and-mouth disease virus (FMDV) infection has been examined. On cells infected with FMDV, class I expression was reduced to approximately 70% of the initial value 3 h after the infection and to 53% after 6 h. On cells depleted of surface class I complexes by acid treatment, the appearance of newly assembled class I-peptide complexes on the cell surface of non-infected cells increased immediately… CONTINUE READING
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