Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

@inproceedings{Dudley2017InfectionVM,
  title={Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques},
  author={Dawn M. Dudley and Christina M Newman and Joseph Lalli and Laurel M. Stewart and Michelle R Koenig and Andrea M. Weiler and Matthew R. Semler and Gabrielle L. Barry and Katie R Zarbock and Mariel S Mohns and Meghan E. Breitbach and Nancy J Schultz-Darken and Eric Jeffrey Peterson and Wendy Newton and Emma L Mohr and Saverio Capuano and Jorge E. Osorio and Shelby L O'Connor and David H. O'Connor and Thomas C Friedrich and Matthew T Aliota},
  booktitle={Nature Communications},
  year={2017}
}
Mouse and nonhuman primate models now serve as useful platforms to study Zika virus (ZIKV) pathogenesis, candidate therapies, and vaccines, but they rely on needle inoculation of virus: the effects of mosquito-borne infection on disease outcome have not been explored in these models. Here we show that infection via mosquito bite delays ZIKV replication to peak viral loads in rhesus macaques. Importantly, in mosquito-infected animals ZIKV tissue distribution was limited to hemolymphatic tissues… CONTINUE READING
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