Infection of the tracheal epithelium by infectious bronchitis virus is sialic acid dependent.

  title={Infection of the tracheal epithelium by infectious bronchitis virus is sialic acid dependent.},
  author={Christine Winter and Georg Herrler and Ulrich Neumann},
  journal={Microbes and infection},
  volume={10 4},
Avian Infectious bronchitis virus (IBV) is a coronavirus that infects chickens via the respiratory epithelium as primary target cells. The binding of coronaviruses to the cell surface is mediated by the viral surface protein S. Recently we demonstrated that alpha2,3-linked sialic acid serves as a receptor determinant for IBV on Vero cells and primary chicken embryo kidney cells. Here we analyze the importance of the sialic acid binding activity for the infection of tracheal organ cultures (TOCs… CONTINUE READING


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