Infection of rat liver epithelial cells with v-Ha-ras: correlation between oncogene expression, gap junctional communication, and tumorigenicity.

@article{Feijter1990InfectionOR,
  title={Infection of rat liver epithelial cells with v-Ha-ras: correlation between oncogene expression, gap junctional communication, and tumorigenicity.},
  author={Annemieke de Feijter and J. S. Ray and Christopher Weghorst and James E Klaunig and Jay I. Goodman and Chia Chien Chang and Randall J. Ruch and James Edward Trosko},
  journal={Molecular carcinogenesis},
  year={1990},
  volume={3 2},
  pages={54-67}
}
The role of v-Ha-ras oncogene in tumorigenesis in an in vitro/in vivo model system was studied by investigating the expression of the Ha-ras gene, gap junctional intercellular communication, and tumorigenicity as endpoints. Infection of a Fischer 344 rat liver epithelial cell line (WB 344) with a retrovirus containing the v-Ha-ras oncogene resulted in altered cell morphology and decreased contact sensitivity. Gap junctional intercellular communication in v-Ha-ras infected WB cells (WBHa-ras… CONTINUE READING

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