Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration.

@article{Prechtel2005InfectionOM,
  title={Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration.},
  author={Alexander T. Prechtel and Nadine M. Turza and Dieter Johannes Kobelt and Jutta I Eisemann and Robert S. Coffin and Yvonne McGrath and Christine Hacker and Xinsheng Ju and Martin Zenke and Alexander Steinkasserer},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 6},
  pages={1645-57}
}
Herpes simplex virus type 1 (HSV-1) is able to establish latency in infected individuals. In order to characterize potential new immune-escape mechanisms, mature dendritic cells (DCs) were infected with HSV-1 and total cellular RNA was isolated from infected and mock-infected populations at different time points. RNA profiling on Affymetrix Human Genome U133A arrays demonstrated a dramatic downregulation of the migration-mediating surface molecules CCR7 and CXCR4, an observation that was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Dendritic cell migration to peripheral lymph nodes.

Handbook of experimental pharmacology • 2009
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…