Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function.

@article{Podinovskaia2013InfectionOM,
  title={Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function.},
  author={Maria Podinovskaia and Wonsik Lee and Shannon Caldwell and David G Russell},
  journal={Cellular microbiology},
  year={2013},
  volume={15 6},
  pages={843-59}
}
The phagosome is a central mediator of both the homeostatic and microbicidal functions of a macrophage. Following phagocytosis, Mycobacterium tuberculosis (Mtb) is able to establish infection through arresting phagosome maturation and avoiding the consequences of delivery to the lysosome. The infection of a macrophage by Mtb leads to marked changes in the behaviour of both the macrophage and the surrounding tissue as the bacterium modulates its environment to promote its survival. In this study… CONTINUE READING

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The uniformity of phagosome maturation in macrophages

The Journal of cell biology • 2004
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