Infection of human synovial cells by human T cell lymphotropic virus type I. Proliferation and granulocyte/macrophage colony-stimulating factor production by synovial cells.

@article{Sakai1993InfectionOH,
  title={Infection of human synovial cells by human T cell lymphotropic virus type I. Proliferation and granulocyte/macrophage colony-stimulating factor production by synovial cells.},
  author={M. Sakai and Katsumi Eguchi and Kaoru Terada and Munetoshi Nakashima and Isao Yamashita and Hiroaki Ida and Yojiro Kawabe and Takahiko Aoyagi and Hirofumi Takino and T. Nakamura},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 4},
  pages={
          1957-66
        }
}
The present study was performed to clarify the relationship between human T cell lymphotropic virus type I (HTLV-I) infection and chronic inflammatory arthropathy. To determine the ability of HTLV-I to infect synovial cells and the effect on synovial cell proliferation, synovial cells were cocultured with the HTLV-I-producing T cell lines (MT-2 or HCT-1). After coculture with HTLV-I-infected T cells, the synovial cells expressed HTLV-I-specific core antigens, and HTLV-I proviral DNA was… 
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48 Citations

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Cytokine production by endothelial cells infected with human T cell lymphotropic virus type I.
OBJECTIVE: To investigate the ability of human T cell lymphotropic virus type I (HTLV-I) to infect endothelial cells and induce cytokine production by these cells. METHODS: Human umbilical vein…
Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
TLDR
It is suggested that HTLV-I infects lung epithelial cells, with subsequent production of cytokines, chemokines and cell adhesion molecules through induction of NF-κB and AP-1.
Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure.
HTLV-I-induced T-cell activation.
  • G. Buckle, D. Hafler, P. Höllsberg
  • Biology, Medicine
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
  • 1996
TLDR
This THTLV-I-T-cell interaction could explain the spontaneous proliferation observed in patients with HTLV-i-associated myelopathy/tropical spastic paraparesis and potentially could provide a basis for some of the diseases associated with HT LV.
Ribozyme-based gene cleavage approach to chronic arthritis associated with human T cell leukemia virus type I: induction of apoptosis in synoviocytes by ablation of HTLV-I tax protein.
TLDR
In vitro results suggest that ribozyme-mediated gene therapy can inhibit the growth of HTLV-I-infected synovial cells, which is maintained by Tax protein, in HTLV -I-related diseases including HAAP.
Direct infection of primary salivary gland epithelial cells by HTLV-I that induces the niche of the salivary glands of Sjögren ’ s syndrome patients
Objective: To explore whether Human T-cell leukemia virus type I (HTLV-I) directly infects salivary gland epithelial cells (SGECs) and induces the niche of Sjögren’s syndrome (SS). Methods: We…
Transactivation of the human interleukin-6 gene by human T-lymphotropic virus type 1 Tax protein.
TLDR
The analysis of a series of deletions of the IL-6 promoter suggested that the region (-105/-47) containing a NF kappa B site was crucial for the Tax responsiveness, indicating an important role of the Tax protein in the expression of IL- 6 in cells infected with HTLV-1.
Mechanism of inhibitory effect of dextran sulfate and heparin on human T-cell lymphotropic virus type I (HTLV-I)-induced syncytium formation in vitro: role of cell-to-cell contact.
The involvement of retroviruses in human T cell leukaemias and lymphomas
TLDR
The hypothesis tested in this study was that HTLV-I,HTLV-II or related viruses are associated with T cell leukaemias and lymphomas in the United Kingdom, particularly mycosis fungoides (MF) and Sezary syndrome (SS).
Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1.
TLDR
It is reported that Tax induces the human prointerleukin-1beta (IL1B) gene promoter in monocytic cells and that recombinant Tax enhances DNA binding of both of recombinant NF-IL6 and Spi-1 proteins.
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