Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.

@article{Ho2004InfectionOH,
  title={Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.},
  author={Ling-Jun Ho and Men-Fang Shaio and D L Chang and Ching-Len Liao and Jenn-Haung Lai},
  journal={Immunological investigations},
  year={2004},
  volume={33 4},
  pages={423-37}
}
Dengue viruses (DV) infection is an important public health issue all over the world. Although the pathogenesis remains unclear, the overwhelmingly triggered immune responses have been consistently observed. Recently, we and other researchers demonstrated that the natural hosts for DV are dendritic cells (DC), the primary sentinels of immune system. In light of the significance of T cells in dengue virus pathogenesis, here, we examine the possible consequences of DC-T cell interaction that is… CONTINUE READING

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