Infection of human bone marrow stromal cells by hepatitis B virus: implications for viral persistence and the suppression of hematopoiesis.

@article{Chai1994InfectionOH,
  title={Infection of human bone marrow stromal cells by hepatitis B virus: implications for viral persistence and the suppression of hematopoiesis.},
  author={Toby Chai and Sandra Prior and William Graham Earnshaw Cooksley and G K Sing},
  journal={The Journal of infectious diseases},
  year={1994},
  volume={169 4},
  pages={871-4}
}
Suspension cultures of bone marrow cells (BMC) were challenged with hepatitis B virus (HBV) to study interactions between the virus and the nonadherent and adherent BMC populations. Virus-challenged BMC developed an adherent stromal layer that differed in cellular composition from that of mock-infected cultures, showing a threefold increase in cells of the monocyte-macrophage lineage with an accompanying decrease in cells of the granulocytic lineage. Both viral envelope hepatitis B surface and… CONTINUE READING