Infection of human airway epithelium by human and avian strains of influenza a virus.

@article{Thompson2006InfectionOH,
  title={Infection of human airway epithelium by human and avian strains of influenza a virus.},
  author={Catherine I. Thompson and Wendy S Barclay and Maria C. Zambon and Raymond J. Pickles},
  journal={Journal of virology},
  year={2006},
  volume={80 16},
  pages={8060-8}
}
We describe the characterization of influenza A virus infection of an established in vitro model of human pseudostratified mucociliary airway epithelium (HAE). Sialic acid receptors for both human and avian viruses, alpha-2,6- and alpha-2,3-linked sialic acids, respectively, were detected on the HAE cell surface, and their distribution accurately reflected that in human tracheobronchial tissue. Nonciliated cells present a higher proportion of alpha-2,6-linked sialic acid, while ciliated cells… CONTINUE READING
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