Infection of cultured rat hepatoma cells by mouse mammary tumor virus.

@article{Ringold1977InfectionOC,
  title={Infection of cultured rat hepatoma cells by mouse mammary tumor virus.},
  author={Gordon M. Ringold and Robert Cardiff and H. E. Varmus and Keith R. Yamamoto},
  journal={Cell},
  year={1977},
  volume={10 1},
  pages={11-8}
}
A continuous line of buffalo rat hepatoma (HTC) cells has been successfully infected with mouse mammary tumor virus (MMTV) produced by the GR mammary tumor cell line. Uniform infection required initial exposure of the HTC cells to greater than 10(5) MMTV particles per cell. The resultant chronically infected cell population was found to have stably acquired 20-30 copies of MMTV DNA. The infected cells contain viral RNA and express viral antigens; however, very few MMTV particles are released… CONTINUE READING