Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus

@article{Cinatl2004InfectionOC,
  title={Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus},
  author={Jindrich Cinatl and Gerold Hoever and Birgit Morgenstern and Wolfgang Preiser and J.-U. Vogel and W. Hofmann and Gerhard Bauer and Martin Michaelis and Holger Felix Rabenau and Hans Wilhelm Doerr},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={2100-2112}
}
To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a… CONTINUE READING