Infection of a human hepatoma cell line by hepatitis B virus.

@article{Gripon2002InfectionOA,
  title={Infection of a human hepatoma cell line by hepatitis B virus.},
  author={Philippe Gripon and Sylvie Rumin and S. Thomas Urban and Jacques Le Seyec and Denise Glaise and Isabelle Cannie and Claire Guyomard and Jennifer Marie Lucas and Christian Tr{\'e}po and Christiane Guguen-Guillouzo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 24},
  pages={
          15655-60
        }
}
Among numerous established human hepatoma cell lines, none has been shown susceptible to hepatitis B virus (HBV) infection. We describe here a cell line, called HepaRG, which exhibits hepatocyte-like morphology, expresses specific hepatocyte functions, and supports HBV infection as well as primary cultures of normal human hepatocytes. Differentiation and infectability are maintained only when these cells are cultured in the presence of corticoids and dimethyl sulfoxide. The specificity of this… CONTINUE READING

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Xenobiotic Metabolism in Epithelial Cell Cultures

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