Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber.

@article{Goossens2001InfectionEO,
  title={Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber.},
  author={Paulien H. Goossens and Menzo Jans Emko Havenga and Elsbet J. Pieterman and Angelique A. C. Lemckert and Ferdinand C. Breedveld and A. Bout and Tom W. J. Huizinga},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 3},
  pages={
          570-7
        }
}
OBJECTIVE To obtain an adenoviral vector with increased infection efficiency in the synovial tissue compared with conventional vectors based on adenovirus serotype 5 (Ad5), without compromising the specificity of infection. METHODS Coxsackie adenovirus receptor (CAR) expression was assessed in cultured synoviocytes. Chimeric adenoviruses based on Ad5 but carrying the DNA encoding the fiber of adenovirus from subgroup B (Adll, 16, 35) or D (Ad24, 28, 33, 45, or 47) were constructed and… CONTINUE READING
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