Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH.

@article{Persaud2018InfectionBZ,
  title={Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH.},
  author={Mirjana Persaud and Alicia Martinez-Lopez and Cindy Buffone and Steven A. Porcelli and Felipe D{\'i}az-Griffero},
  journal={Virology},
  year={2018},
  volume={518},
  pages={301-312}
}
The recent Zika virus (ZIKV) outbreak in Brazil has suggested associations of this virus infection with neurological disorders, including microcephaly in newborn infants and Guillian-Barré syndrome in adults. Previous reports have shown that AXL, a transmembrane receptor tyrosine kinase protein, is essential for ZIKV infection of mammalian cells, but this remains controversial. Here, we have assessed the involvement of AXL in the ability of ZIKV to infect mammalian cells, and also the… CONTINUE READING
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