Infection breaks T-cell tolerance

  title={Infection breaks T-cell tolerance},
  author={Martin R{\"o}cken and Joseph J. Urban and Ethan M Shevach},
CLONAL deletion or clonal anergy establish tolerance in T cells that bear potentially autoreactive antigen receptors1–15. Here we report that concomitant infection with the nematode Nippostron-gylus brasiliensis breaks an established T-cell tolerance induced by injection of mice with Staphylococcus enterotoxin B (SEB)16,17. CD4+ T cells from SEB-tolerant mice did not produce either interleukin-2 or interleukin-4 when challenged in vitro with SEB. N. brasiliensis infection of SEB-primed animals… CONTINUE READING
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