Infection-associated macrophage activation accelerates chronic renal allograft rejection in rats.


BACKGROUND The influence of infection-associated cellular activation on chronic rejection of kidney grafts was assessed in an established rat model by administration of lipopolysaccharide (LPS), an endotoxin and a potent stimulator of various cell populations including mononuclear cells and renal epithelial cells. METHODS Lewis recipients of F344 kidneys… (More)