Infection and Inflammation in Schizophrenia and Bipolar Disorder: A Genome Wide Study for Interactions with Genetic Variation

@inproceedings{Avramopoulos2015InfectionAI,
  title={Infection and Inflammation in Schizophrenia and Bipolar Disorder: A Genome Wide Study for Interactions with Genetic Variation},
  author={Dimitrios Avramopoulos and Bradley D. Pearce and J J Mcgrath and Paula S. Wolyniec and Ruihua Wang and Nicole Eckart and Alexandros Hatzimanolis and Fernando S. Goes and Gerald Nestadt and Jennifer Gladys Mulle and Karen Coneely and Myfanwy H. Hopkins and Ingo Ruczinski and Robert Yolken and Ann E Pulver},
  booktitle={PloS one},
  year={2015}
}
Inflammation and maternal or fetal infections have been suggested as risk factors for schizophrenia (SZ) and bipolar disorder (BP). It is likely that such environmental effects are contingent on genetic background. Here, in a genome-wide approach, we test the hypothesis that such exposures increase the risk for SZ and BP and that the increase is dependent on genetic variants. We use genome-wide genotype data, plasma IgG antibody measurements against Toxoplasma gondii, Herpes simplex virus type… CONTINUE READING
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