Infected Cell Protein ( ICP ) 47 Enhances Herpes Simplex Virus Neurovirulence by Blocking the CD 8 1 T Cell Response

The herpes simplex virus (HSV) infected cell protein (ICP)47 blocks CD8 1 T cell recognition of infected cells by inhibiting the transporter associated with antigen presentation (TAP). In vivo, HSV-1 replicates in two distinct tissues: in epithelial mucosa or epidermis, where the virus enters sensory neurons; and in the peripheral and central nervous system… CONTINUE READING