Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature.

@article{Ran1998InfarctionOS,
  title={Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature.},
  author={Sophia Ran and Boning Gao and Steve Duffy and Linda Watkins and Neal S. Rote and Philip E. Thorpe},
  journal={Cancer research},
  year={1998},
  volume={58 20},
  pages={4646-53}
}
We demonstrated previously that selective thrombosis of the blood vessels of solid tumors in mice can be achieved by targeting the extracellular domain of tissue factor by means of an antibody to an experimentally induced marker on tumor vascular endothelium. In the present study, we extend this finding to a naturally occurring marker of tumor vascular endothelium, vascular cell adhesion molecule-1 (VCAM-1). VCAM-1 is expressed by vascular endothelial cells in Hodgkin's disease and various… CONTINUE READING