Infarct-sparing effect of A2A-adenosine receptor activation is due primarily to its action on lymphocytes.

@article{Yang2005InfarctsparingEO,
  title={Infarct-sparing effect of A2A-adenosine receptor activation is due primarily to its action on lymphocytes.},
  author={Zequan Yang and Yuan-Ji Day and Marie-Claire Toufektsian and Susan I. Ramos and Melissa A. Marshall and Xin-qun Wang and Brent A. French and Joel M Linden},
  journal={Circulation},
  year={2005},
  volume={111 17},
  pages={2190-7}
}
BACKGROUND A2A-adenosine receptor (A2AAR) activation on reperfusion after ischemia reduces the size of myocardial infarction, but the mechanism of action has not been fully defined. METHODS AND RESULTS We created chimeric mice by bone marrow transplantation from A2AAR-knockout or green fluorescent donor mice to irradiated congenic C57BL/6 (B6) recipients. In the GFP chimeras, we were unable to detect green fluorescent-producing cells in the vascular endothelium, indicating that bone marrow… CONTINUE READING

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Beneficial effects of adenosine A(2a) agonist CGS-21680 in infarcted and stunned porcine myocardium

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