Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts.

@article{Akizuki1985InfarctSL,
  title={Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts.},
  author={S. Akizuki and S. Yoshida and D E Chambers and Lynne J. Eddy and Loren F. Parmley and DM Yellon and J. M. Downey},
  journal={Cardiovascular research},
  year={1985},
  volume={19 11},
  pages={
          686-92
        }
}
The present study was designed to evaluate the ability of allopurinol to limit infarct size following permanent coronary occlusion in the greyhound. Coronary occlusion was produced by injecting 2.5 mm plastic beads into the coronary artery of the closed chest dog. Non-perfused myocardium, the area at risk, was visualised by autoradiography of 141Cerium labelled microspheres which were infused immediately following coronary embolization. The treated dogs (n = 12) received 400 mg of allopurinol… 
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Protection afforded by allopurinol in the first 24 hours of coronary occlusion is diminished after 48 hours.
Xanthine Oxidase Inhibition Does Not Limit Canine Infarct Size
TLDR
Xanthine oxidase inhibition was demonstrated in each of the drug treatment groups, but only oxypurinol limited the extent of myocardial injury, unrelated to inhibition of superoxide formation during xanthine oxidation-catalyzed oxidation ofxanthine and hypoxanthine.
The xanthine oxidase inhibitor oxypurinol does not limit infarct size in a canine model of 40 minutes of ischemia with reperfusion.
Chronic administration of allopurinol fails to exert any cardioprotective effect in rats submitted to permanent coronary artery ligation
TLDR
It is concluded that the enzyme xanthine oxidase is probably not involved in the pathophysiology of myocardial infarction in the rat because of the absence of collateral vasculature in this species which prevents any oxygen supply to the ischemic zone.
Limitation of experimental myocardial infarct size by magnesium sulfate pre-treatment in dogs.
  • A. Lal, S. Sharma
  • Medicine, Biology
    Indian journal of physiology and pharmacology
  • 1990
TLDR
It is concluded that magnesium sulfate exerted a potent prophylactic effect in limiting the infarct size in the dogs with permanent coronary artery occlusion.
Coronary venous retroinfusion of deferoxamine reduces infarct size in pigs.
Modulation of catecholamine cardiomyopathy by allopurinol.
Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion-reperfusion model.
Determinants of infarct size during permanent occlusion of a coronary artery in the closed chest dog.
Effects of allopurinol on myocardial ischemic injury induced by coronary artery ligation and reperfusion.
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References

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TLDR
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