Infantile osteopetrosis complicating neuronal ceroid lipofuscinosis.

  title={Infantile osteopetrosis complicating neuronal ceroid lipofuscinosis.},
  author={Kenzo Takahashi and Masaaki Naito and Fuyuhiko Yamamura and Toshihiko Taki and Shigeru Sugino and Kazuo Taku and Teruhisa Miike},
  journal={Pathology, research and practice},
  volume={186 6},
An autopsy case of infantile osteopetrosis complicating neuronal ceroid-lipofuscinosis is reported. Autopsy revealed generalized sclerosis and thickening of cortical and spongy bones, formation of mineralized cartilagenous tissues, and narrowing of the marrow cavities associated with decreased hematopoietic cell components. Around the thickened bone trabecles, osteoclasts lacked a ruffled border and clear zone along the cell membrane facing the bone matrix surface. The brain was markedly… CONTINUE READING