Infantile onset of hereditary ascending spastic paralysis with bulbar involvement.

@article{LermanSagie1996InfantileOO,
  title={Infantile onset of hereditary ascending spastic paralysis with bulbar involvement.},
  author={Tally Lerman-Sagie and Jim Filiano and David W. Smith and Mark Korson},
  journal={Journal of child neurology},
  year={1996},
  volume={11 1},
  pages={54-7}
}
Primary lateral sclerosis and hereditary spastic paraparesis are both rare neurodegenerative disorders characterized by progressive weakness and spasticity of the lower limbs, with involvement of the corticospinal tracts and sparing of anterior horn cells. We describe a consanguineous family in which three sons developed progressive paralysis of the lower extremities in infancy with subsequent involvement of the upper extremities and bulbar muscles but cognitive sparing. This family presents… CONTINUE READING