Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment.

@article{Nguyen2010InfantileHA,
  title={Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment.},
  author={Minh Thanh Nguyen and Henri Boutignon and Eric Mallet and Agn{\`e}s Linglart and Huguette Guillozo and Fr{\'e}d{\'e}ric Jehan and Mich{\`e}le Garab{\'e}dian},
  journal={The Journal of pediatrics},
  year={2010},
  volume={157 2},
  pages={296-302}
}
OBJECTIVE To analyze vitamin D metabolism and response to ketoconazole, an imidazole derivative that inhibits the vitamin D-1-hydroxylase, in infants with idiopathic hypercalcemia, and hypercalciuria. STUDY DESIGN Twenty infants (4 days-17 months) with hypercalcemia, severe hypercalciuria, and low parathyroid hormone level, (10 had nephrocalcinosis), including 10 treated with ketoconazole (3-9 mg/kg/day), were followed to the age of 2 to 51 months. Vitamin D receptor expression (VDR), 24… CONTINUE READING
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