Infant rats can acquire, but not retain contextual associations in object-in-context and contextual fear conditioning paradigms.

  title={Infant rats can acquire, but not retain contextual associations in object-in-context and contextual fear conditioning paradigms.},
  author={Hollie R Sanders and Nicholas A Heroux and Mark E Stanton},
  journal={Developmental psychobiology},
Context learning in postnatal day (PD) 16-18 rats has been taken by Revillo, Cotella, Paglini, and Arias (2015, Physiology & Behavior, 148, 6-21) to challenge the view that the ontogeny of contextual learning is related to the development of the hippocampal system (Rudy, 1993, Behavioral Neuroscience, 107(5), 887-891; Schiffino, Murawski, Rosen, & Stanton, 2011 Neurobiology of Learning and Memory, 95(2), 190-198). Whether context learning is "incidental" or "reinforcement-driven" may determine… 
Unfolding of spatial representation at systems level in infant rats.
Functional representations of space at a systems level are formed already in pre‐weanling rats, suggesting that the pups relied more on proximal than distal cues during spatial exploration.
Eating behavior as a new frontier in memory research


Role of age, post-training consolidation, and conjunctive associations in the ontogeny of the context preexposure facilitation effect.
These results are the first to show that the early development of contextual fear conditioning depends on conjunctive representations and that processes underlying the CPFE begin to emerge around PND 21 in the rat.
Ontogeny of Contextual Fear Conditioning in Rats: Implications for Consolidation, Infantile Amnesia, and Hippocampal System Function
The authors present developmental evidence that contextual fear conditioning is supported by a short-term memory system that supports conditioning immediately after a shock and by a long-term memory
The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
Together, these data dissociate hippocampal and nonhippocampal contributions to contextual conditioning, and they provide direct evidence that the hippocampus plays an essential role in the processing of contextual stimuli.
Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.
A role of cholinergic signaling in hippocampus is demonstrated during each of the 3 phases of the context preexposure facilitation effect in adolescent rats during each phase of the CPFE protocol.
Contextual conditioning and auditory cue conditioning dissociate during development.
  • J. W. Rudy
  • Psychology, Biology
    Behavioral neuroscience
  • 1993
The developmental dissociation between contextual and auditory cue conditioning parallels the dissociation produced by damage to the adult rat's hippocampal system as well as the developmental hypothesis that the configural association system develops late in comparison with the elemental association system.
Determinants of object-in-context and object-place-context recognition in the developing rat.
The present study reports that long-term retention of object-in-context (OiC) memory emerges during early development in the rat, and that performance ofobject-place- context (OPC), a spatial variant of the OiC task, also displays protracted development until early adolescence.