Infant nerve injury induces delayed microglial polarization to the M1 phenotype, and exercise reduces delayed neuropathic pain by modulating microglial activity.

Abstract

Neuropathic pain is absent in infants and emergent years after injury. Adult spinal cord microglia play a key role in initiating neuropathic pain, and modulation of microglia is a potential target for treating neuropathic pain. In this study, we evaluated the role of microglia after infant peripheral nerve injury and the effect of exercise on the delayed… (More)
DOI: 10.1016/j.neuroscience.2017.02.051

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Cite this paper

@article{Gong2017InfantNI, title={Infant nerve injury induces delayed microglial polarization to the M1 phenotype, and exercise reduces delayed neuropathic pain by modulating microglial activity.}, author={Xingrui Gong and Yongmei Chen and Bao Fu and Jing Jiang and Mazhong Zhang}, journal={Neuroscience}, year={2017}, volume={349}, pages={76-86} }