Infant acute lymphoblastic leukemia: a 20-year children's hospital experience.

@article{Murray2008InfantAL,
  title={Infant acute lymphoblastic leukemia: a 20-year children's hospital experience.},
  author={Rebecca Anne Murray and Giddel G A Thom and Renee V Gardner and Randall D. Craver},
  journal={Fetal and pediatric pathology},
  year={2008},
  volume={27 4-5},
  pages={
          197-205
        }
}
We reviewed our 20-year experience with infant acute lymphoblastic leukemia (ALL). Nine infants (4.2% of all ALL) were identified; all were < 6 months of age. White blood cell counts ranged from 42,000-1.6 million/microL, 6 of 8 had hepatosplenomegaly, and 6 of 9 (66.6%) had central nervous system disease. Of 7 with cytogenetic information, 6 (85.7%) had diploidy; the remaining child was 47, XY,+8,del(21)(q22). Four had the MLL-11q23 abnormality. All received chemotherapy. Four underwent stem… CONTINUE READING
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