Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias.

@article{Cimino1997InfantAL,
  title={Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias.},
  author={Guido Cimino and Maria Cristina Rapanotti and Andrea Biondi and Loredana Elia and Francisco Lo Coco and Christopher R. Price and V. Dal Pozzo Rossi and Antonella Rivolta and Eli Canaani and Carlo M. Croce and Franco Mandelli and Mel Greaves},
  journal={Cancer research},
  year={1997},
  volume={57 14},
  pages={2879-83}
}
The ALL1 gene (also called MLL, HRX, or Htrx1) at the cytogenetic band 11q23 is consistently altered by chromosome rearrangements in acute leukemias (ALs) of early infancy, in ALs developed after exposure to topoisomerase (topo) II-inhibitory drugs, and in a small subset of de novo ALs in children and adults. Because exposure to natural or medicinal substances blocking topo II during pregnancy have been proposed as etiological agents for infant leukemia, we have compared the distribution of… CONTINUE READING

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