Infant Botulism: Two Recent Cases and Literature Review

@article{Domingo2008InfantBT,
  title={Infant Botulism: Two Recent Cases and Literature Review},
  author={R. Domingo and Jerome S. Haller and Michael Gruenthal},
  journal={Journal of Child Neurology},
  year={2008},
  volume={23},
  pages={1336 - 1346}
}
Infant botulism is a cause for significant pediatric morbidity in the United States, though early recognition and supportive care can greatly improve clinical outcomes. Since the approval of human botulism immune globulin by the United States Food and Drug Administration (FDA) for the treatment of infant botulism in 2003, the importance of prompt initiation of therapy has been emphasized, with clinical suspicion remaining the mainstay of diagnosis. In this report, 2 cases of infant botulism are… Expand
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TLDR
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TLDR
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TLDR
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Constipation and poor feeding in an infant with botulism
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A 5-month-old previously well infant taken to the emergency department because of parental concerns about constipation and feeding difficulties had not had any bowel movements at the time of assessment. Expand
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References

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TLDR
It is suggested that disease caused by different toxin types may result in varying clinical presentations, and increasing therapeutic use of botulinum toxins has sparked substantial new research into their mechanisms of action. Expand
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TLDR
This article reports the youngest known case of infant botulism and only the third reported case of this disease caused by type F neurotoxin, and should be considered in patients of any age with subacute or acute neuromuscular weakness. Expand
Infant botulism: clinical spectrum and epidemiology.
TLDR
Observations from patients suggest an expanded clinical spectrum of infant botulism including asymptomatic carriers of organism; mild hypotonia and failure to thrive; typical cases with constipation, bulbar weakness, and hypotonia; and children with a picture compatible with sudden infant death syndrome. Expand
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TLDR
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The first two cases of infant botulism in Italy are described, which are also the first cases anywhere to have been caused by type E botulinal toxin, which enhances the significance of the recent report of isolation of a Clostridium barati strain that produced type F botulINAL toxin. Expand
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TLDR
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